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• Peripheral neuropathy = Arsenic, Mercury
• Alterations in peripheral nerves = Arsenic
• Loss of feeling/ numbness in the extremities; paresthesia = Arsenic, Mercury, Thalliu
• Nausea, vomiting, diarrhea; loss of appetite = Arsenic, Copper, Mercury, Thallium
• Abdominal pain, stomach cramps; burning of the throat and mouth = Arsenic, Copper, Lead, Mercury, Thallium
• Esophagitis; gastroenteritis; colitis = Arsenic, Mercury, Thallium
• Cancers (colon, pancreatic, stomach, or rectal) = Arsenic

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• Neurofibrillary tangles = Aluminum
• Neuritis, retrobulbar neuritis; neuropathy = Aluminum, Arsenic, Thallium
• Encephalopathy = Aluminum, Arsenic, Lead, Thallium
• Cerebrovascular disease = X Metals
• Alterations in nerve conduction velocity = Lead
• Alterations in the spinal chord = Thallium
• Accumulates in CNS structures = Aluminum, Mercury
• Abnormal EEGs = Arsenic, Lead

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• Choreiform movements, myoclonal jerks, unusual postures = Copper, Mercury

• Difficulty walking, swallowing, talking = Copper, Mercury
• Flapping, circling, rocking, toe walking = Mercury
• Problems with intentional movements or imitation = Mercury
• Abnormal gait/posture; incoordination, loss of balance; problems sitting, lying, crawling, and walking = Mercury
• Decreased locomotor activity = Aluminum, Arsenic
• Convulsions; seizure = Aluminum, Arsenic, Copper, Lead, Mercury, Thallium

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• Abnormal Sensations in the mouth and extremities = Arsenic
• Hearing loss, difficulty hearing = Arsenic, Lead, Mercury
• Abnormal touch sensations; diminished touch sensations, aversion to touch = Arsenic
• Blurred vision; sensitivity to light = Arsenic, Mercury

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• Attention problems (ADHD), lacks eye contact, impaired visual fixation = Lead, Mercury
• Mental retardation, borderline intelligence = Arsenic, Lead, Mercury
• Uneven performance on IQ scores, low IQ scores = Copper, Lead
• Poor concentration, attention deficits (ADHD), response inhibition = Aluminum, Lead
• Poor memory (short term, verbal, and auditory) = Aluminum, Lead
• Difficulties understanding abstract ideas; difficulty carrying out complex commands = X Metals
• Dementia; pre-senile and senile dementia = Aluminum
• Stupor = Aluminum, Arsenic
• Impaired reaction time; lower performance on timed tests = Lead

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• Speech disorders = Aluminum, Mercury

• Developmental problems with language = Mercury
• Speech comprehension deficits  =  Mercury
• Dysarthria; articulation problems; slurred speech, unintelligible speech = Mercury

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